MEDSCI 715 : Molecular Toxicology

Medical and Health Sciences

2021 Semester One (15 POINTS)

Course Prescription

Covers the current understanding of mechanisms implicated in toxicity of drugs and environmental chemicals plus the basis of inter-individual susceptibility. The course identifies strategies used to predict and prevent adverse reactions during drug development.

Course Overview

This course involves advanced study into the role of metabolism (including induction/inhibition and genetic polymorphisms) in the toxicity of xenobiotics and molecular events following exposure to toxic xenobiotics, such as mutagenesis, teratogenesis and apoptosis. The toxicity of several classes of drugs, including anticancer, antibacterial and antimalarial drugs is also studied in detail

Course Requirements

No pre-requisites or restrictions

Course Contacts

m.tingle@auckland.ac.nz

Capabilities Developed in this Course

Capability 1: Disciplinary Knowledge and Practice
Capability 2: Critical Thinking
Capability 3: Solution Seeking
Capability 4: Communication and Engagement
Capability 5: Independence and Integrity
Capability 6: Social and Environmental Responsibilities

Learning Outcomes

By the end of this course, students will be able to:
  1. Demonstrate an understanding of the principles important to predicting adverse reactions to compounds, whether they be under development as a drug or through environmental exposure (Capability 1 and 2)
  2. Demonstrate a comprehensive knowledge of biological targets and the damage caused to such targets plus some of the ensuing changes at the level of organelle, cell, organ and organism (Capability 1, 2 and 4)
  3. Evaluate the relevance of non-clinical species to the prediction of human drug safety (Capability 1, 4 and 6)
  4. Apply scientific reasoning and methods to experimental design for assessment of chemical toxicity (Capability 1, 2, 3 and 4)
  5. Apply critical evaluation to identify the essentials of scientific information in written reports and oral presentation (Capability 1, 2, 4 and 5)

Assessments

Assessment Type Percentage Classification
Assignments 40% Individual Coursework
Final Exam 60% Individual Examination
Assessment Type Learning Outcome Addressed
1 2 3 4 5
Assignments
Final Exam

Workload Expectations

This course is a standard 15 point course and students are expected to spend 10 hours per week involved in each 15 point course that they are enrolled in.

For this course, you can expect 2 hours of lectures and  2 hours of reading and thinking about the content per week and 102 hours of work on assignments and exam preparation.

Delivery Mode

Campus Experience

Attendance is expected at scheduled activities including tutorials to complete credit for components of the course.
Lectures will be available as recordings. Other learning activities including tutorials will not be available as recordings.
The course will include live online events including group discussions/tutorials.
Attendance on campus is required for the exam.
The activities for the course are scheduled as a standard weekly timetable.

Learning Resources

All learning resources will be made available through CANVAS or the University library services

Student Feedback

At the end of every semester students will be invited to give feedback on the course and teaching through a tool called SET or Qualtrics. The lecturers and course co-ordinators will consider all feedback and respond with summaries and actions.

Your feedback helps teachers to improve the course and its delivery for future students.

Class Representatives in each class can take feedback to the department and faculty staff-student consultative committees.

Digital Resources

Course materials are made available in a learning and collaboration tool called Canvas which also includes reading lists and lecture recordings (where available).

Please remember that the recording of any class on a personal device requires the permission of the instructor.

Academic Integrity

The University of Auckland will not tolerate cheating, or assisting others to cheat, and views cheating in coursework as a serious academic offence. The work that a student submits for grading must be the student's own work, reflecting their learning. Where work from other sources is used, it must be properly acknowledged and referenced. This requirement also applies to sources on the internet. A student's assessed work may be reviewed against online source material using computerised detection mechanisms.

Inclusive Learning

All students are asked to discuss any impairment related requirements privately, face to face and/or in written form with the course coordinator, lecturer or tutor.

Student Disability Services also provides support for students with a wide range of impairments, both visible and invisible, to succeed and excel at the University. For more information and contact details, please visit the Student Disability Services’ website http://disability.auckland.ac.nz

Special Circumstances

If your ability to complete assessed coursework is affected by illness or other personal circumstances outside of your control, contact a member of teaching staff as soon as possible before the assessment is due.

If your personal circumstances significantly affect your performance, or preparation, for an exam or eligible written test, refer to the University’s aegrotat or compassionate consideration page https://www.auckland.ac.nz/en/students/academic-information/exams-and-final-results/during-exams/aegrotat-and-compassionate-consideration.html.

This should be done as soon as possible and no later than seven days after the affected test or exam date.

Learning Continuity

In the event of an unexpected disruption we undertake to maintain the continuity and standard of teaching and learning in all your courses throughout the year. If there are unexpected disruptions the University has contingency plans to ensure that access to your course continues and your assessment is fair, and not compromised. Some adjustments may need to be made in emergencies. You will be kept fully informed by your course co-ordinator, and if disruption occurs you should refer to the University Website for information about how to proceed.

The delivery mode of this course may change in accordance with changes to New Zealand Government recommendations. Updates for this course will be provided on the course Canvas page.
[This course may be taken remotely, including tests and exams, if you meet Ministry of Health guidelines and receive an exemption, or are unable to attend because of border restrictions.] OR [Note: this course cannot be taken remotely at Level 1]
Level 1: All main teaching activities will be conducted on campus and in person.
• Lectures: on campus, recorded lectures will  be available.
• Tutorials: on campus, remote versions will not be available.
• Exams: on campus, you must attend in person unless you are unwell or other circumstances outside your control prevent you from attending. You must complete the exam to pass the course. 
Level 2: All teaching activities are remote
• Lectures: delivered remotely, available at the timetabled time and recorded lectures will be available
• Tutorials: delivered remotely, available at the timetabled time and recorded versions will be available
• Exams: delivered remotely at timetabled time. You must complete the exam to pass the course. 
Level 3/4: All teaching activities are remote
• Lectures, tutorials: delivered remotely, available at the timetabled time and recordings of the sessions/online versions will be available.
• Exams: delivered remotely at timetabled time. You must complete the exam to pass the course. 

Student Charter and Responsibilities

The Student Charter assumes and acknowledges that students are active participants in the learning process and that they have responsibilities to the institution and the international community of scholars. The University expects that students will act at all times in a way that demonstrates respect for the rights of other students and staff so that the learning environment is both safe and productive. For further information visit Student Charter https://www.auckland.ac.nz/en/students/forms-policies-and-guidelines/student-policies-and-guidelines/student-charter.html.

Disclaimer

Elements of this outline may be subject to change. The latest information about the course will be available for enrolled students in Canvas.

In this course you may be asked to submit your coursework assessments digitally. The University reserves the right to conduct scheduled tests and examinations for this course online or through the use of computers or other electronic devices. Where tests or examinations are conducted online remote invigilation arrangements may be used. The final decision on the completion mode for a test or examination, and remote invigilation arrangements where applicable, will be advised to students at least 10 days prior to the scheduled date of the assessment, or in the case of an examination when the examination timetable is published.