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Many sciences use computational methods that involve the development and application of computer algorithms and software to answer scientific questions. This course looks at how to tackle these interdisciplinary problems through methods like probabilistic computer modelling, computer-based statistical inference, and computer simulations. The material is largely motivated by the life sciences but also uses examples from other sciences. It focuses on modelling and analysing real-world data with an emphasis on analysing DNA sequence data. No background in physical or life sciences is assumed.