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Examines the molecular and cellular processes underlying cancer treatment and the development of tumour-selective therapy; the principles of radiotherapy and chemotherapy; DNA and the basis for its interactions with anticancer drugs; recognition of DNA by proteins; exploitation of these processes by anticancer drugs, oncogenes and other regulatory gene products; signal transduction mechanisms and strategies for changing cell cycle control; cytokines and the role of host responses in cancer therapy; new approaches to cancer therapy including gene therapy and photodynamic therapy.

Advanced studies of concepts related to the biology of cancer. These will include: molecular mechanisms, signal transduction pathways, genomic instability, telomeres and telomerase, anoikis, DNA damage sensing mechanisms, and hypoxia and tumour progression.

Covers the current understanding of mechanisms implicated in toxicity of drugs and environmental chemicals plus the basis of inter-individual susceptibility. The course identifies strategies used to predict and prevent adverse reactions during drug development.

Advanced study of the absorption, distribution, metabolism and excretion of drugs, and the analysis of these processes. Also included are: in vivo/in vitro techniques in drug ADME studies used in drug development; drug analysis in biological matrices; and pharmaco-genomic aspects related to drug disposition.

An advanced study of current research topics in neuroscience. Involves critical analysis of the literature within the context of a series of major research themes that encompass models from molecular through to systems level neuroscience. Themes will be selected from the following areas: neurogenesis, neurodegeneration and/or addiction.

General aspects of anaesthetics and analgesics. Topics covered include the development of modern anaesthesia, the mechanisms of action of drugs used in general and local anaesthesia, and issues surrounding safety and efficacy of anaesthesia, including drug error and circadian variation in drug action.

An introduction to the application of mathematical models used in the interpretation of pharmacological observations. Computer-based analysis methods are investigated using individual and population-oriented approaches.

An introduction to some of the most commonly used techniques used in today's research laboratories; from tissue culture to confocal microscopy, RT-PCR to mass spectrometry, immunoassay to cloning. Emphasis is placed on understanding the principles behind the techniques, how they are applied to address specific questions, and how to evaluate and use the data they generate.

Focuses on classes of drugs associated with idiosyncratic adverse reactions and studies to define their metabolic basis and assessment of toxic risk.

The disposition and action of medicines in humans of all ages will be explored, as well as adverse reactions, effects of pregnancy, medicine classification, and evaluation of clinical trials. Emphasis is placed on understanding the sources of variability of medicines and the use of target concentration intervention.

The pharmacological basis of the action of anti-tumour drugs relevant to human cancer therapy, emphasising the variability of chemotherapy effects, interactions between anti-cancer agents and early phase clinical trials.

An advanced treatment of selected topics in neurophysiology and brain pathophysiology. Includes presentations and critical analysis by the students of the current scientific literature within the context of several major research themes that encompass models from molecular and cellular to systems level. Themes will be selected from the following areas: (1) motor control and motor disorders; (2) synapse physiology and pathophysiology; (3) advances in neural stem cell research; and (4) physiology and pathophysiology of CNS glia.

Molecular regulation and coordination of normal reproduction. The reproductive disorders that arise when normal biological processes are disrupted. Recent molecular methods have enabled us to study these processes and to understand how they can go wrong. Genomic and proteomic approaches to the understanding of reproduction and reproductive disorders will be presented. Examination of the new technologies that allow us to overcome some of these reproductive problems.

Focusses on recent scientific advances in the field of human reproductive biology and medicine, with an emphasis on developing critical thinking skills. Examines the scientific approaches used to understand normal and pathological pregnancies, recent advances in reproductive medicine, and the ethical implications and considerations of assisted reproductive technologies.

Explores how hormones are able to control such a wide range of physiological processes. Covers molecular aspects of hormone action with particular reference to the neuroendocrine and peripheral endocrine systems that control appetite and metabolism. Other topics covered include how defects in hormone action lead to diseases such as cancer, obesity, Type-2 diabetes and cardiovascular disease.

Examines the current state of the field of research relating to cardiovascular physiology, including critical analysis of the literature. This course portrays how an integrative physiological approach can reveal new levels of understanding in the field of cardiovascular research. Examples of this approach will be drawn from research programmes within the broad area of cardiovascular biology.

Explores cellular and molecular mechanisms of drug action and drug discovery and development from the perspective of in silico modelling, biochemical assessment, intracellular signalling and human disease. Considers the pharmacokinetic processes involved in achieving clinically-relevant drug concentrations, the link between concentration and effect, the time course of effect and factors that may influence both clinical effectiveness and drug toxicity.

Chronobiology – the study of biological rhythms and the clocks that control them. Theory, anatomical location and molecular machinery of biological clocks will be covered, as will the control of rhythms of different time scales from days (circadian rhythms) to years (circannual rhythms). The influence the human circadian clock has on physiology and drug efficacy, and the effect hospitalisation has on the control of sleep cycles will be given special attention.

Advanced study of the physiology of neurosensory systems in health and disease. Provides an in-depth coverage of the molecular, cellular and systemic mechanisms underlying vision and hearing.

An in-depth exploration of the principles of experimental design and data analysis in biomedical contexts. A focus on critical appraisal of choice of statistical tests to address experimental questions and appropriateness and limitations of analysis and interpretation of results will be undertaken. Practical and computer statistical packages are used.

An individualised course of study in which each student will provide an exposition of the background to a specific research question in the biomedical sciences combined with a proposal of the best methods to investigate that specific question. A holistic consideration, including the ethical, regulatory, budgetary as well as, any other relevant aspects, of the chosen methods will be documented.

An individualised course of study in which each student will provide an exposition of the background to a specific research question in the biomedical sciences combined with a proposal of the best methods to investigate that specific question. A holistic consideration, including the ethical, regulatory, budgetary as well as, any other relevant aspects, of the chosen methods will be documented.

Examines approaches for bringing potential new therapeutic drugs from the discovery bench into the clinic and the drug development process. Explores a variety of drugs and uses case studies to provide a practical understanding. Integrates multidisciplinary perspectives, drawn from academic and industry experiences, on practices that contribute to the development of safe and effective drug therapies.

An in-depth exploration of the importance of the early life nutritional environment for health across the life course including critical appraisal of evidence from epidemiological, clinical, and pre-clinical studies.

Provides an opportunity for the application of specific and selected topics from the biological and physical sciences to be related to beginning nursing practice.