MEDSCI 301 : Molecular Basis of Disease

Medical and Health Sciences

2020 Semester Two (1205) (15 POINTS)

Course Prescription

An in-depth analysis of the cellular and molecular basis of disease, including the role of environmental and inherited risk factors, as well as mechanisms of response to cell injury and inflammation in the disease process. A number of examples will be studied including cancer and infectious disease.

Course Overview

This course aims to study in detail the basis of disease at a cellular and molecular level. Individual disease examples will be used to illustrate how toxicants, infectious agents, genetic factors (inherited and neoplastic) and immune-mediated processes cause human disease. This is known as molecular pathology.
The primary delivery of material is by lectures (3 per week) and there are 3 hour laboratory-based or workshop sessions every alternate week.

Lectures are based around four modules with the following themes:
• Toxicant injury & its effect on organ function
• Infectious & immune mediated diseases
• Genetic (inherited) diseases
• Neoplasia (cancer)


Course Requirements

Prerequisite: MEDSCI 203

Capabilities Developed in this Course

Capability 1: Disciplinary Knowledge and Practice
Capability 2: Critical Thinking
Capability 4: Communication and Engagement
Capability 5: Independence and Integrity
Graduate Profile: Bachelor of Science

Learning Outcomes

By the end of this course, students will be able to:
  1. Demonstrate your knowledge and understanding of molecular pathogenesis and the functional consequences of disease (Capability 1)
  2. Demonstrate your ability to recognise, report and interpret key features of human diseases using terminology appropriate to the discipline (Capability 1, 2 and 5)
  3. Demonstrate your ability to appropriately communicate information (written and oral) to peers and discipline-based experts (Capability 4 and 5)

Assessments

Assessment Type Percentage Classification
Final Exam 45% Individual Examination
Test 10% Individual Test
Presentation 8% Individual Coursework
Laboratories 24% Individual Coursework
Self-directed assignment 8% Individual Coursework
Workshops 5% Individual Coursework
Assessment Type Learning Outcome Addressed
1 2 3
Final Exam
Test
Presentation
Laboratories
Self-directed assignment
Workshops

A miminum mark of 50% in the final examination and a minimum of 50% in the coursework is required to pass this course.

Attendance at the laboratory-based session is compulsory. Please contact the Course Coordinator if you have any difficulties attending a session.

Late submission of work/penalties 

To apply for an extension, students need to contact the Course Coordinator and supply documentation (e.g. doctor’s certificate/collaborating note from a counsellor) before the due date. Please note that your application is a request only and it should not be assumed that an extension will be granted. Retrospective approval for an extension will be given only in exceptional circumstances.

Except where the Course Coordinator has authorised an extension of time for the submission of student work, work handed in after the deadline will incur a late penalty of 5% for each 12-hour period (or part thereof) that the assessment is overdue. This applies to all written work, including but not limited to lab reports, essays, seminar papers / presentations, assignments, posters, etc. Submission of written work is only complete when an electronic copy has been submitted through the appropriate platform (e.g. Turnitin or Canvas). Please retain your submission confirmation e-receipt / take a timestamped screenshot as evidence of timely submission.   

Aegrotat or compassional consideration for coursework 

If you believe illness, injury or personal misfortune has affected the quality of your submitted work, you can apply for aegrotat or compassionate consideration.

Learning Resources

 A number of  learning resources, in addition to the lecture material, will be available to you during this course. These include access to   the AMRF-Medical Sciences Learning Centre, virtual histopathology microscopy material and  WebPath.

Course Contacts

Course Director 
Dr  Nuala Helsby
n.helsby@auckland.ac.nz

Course Coordinator 
Dr Rachelle Singleton
r.singleton@auckland.ac.nz

Workload Expectations

This course is a standard 15 point course and students are expected to spend 10 hours per week involved in each 15 point course that they are enrolled in.

For this course, you can expect 33 hours of lectures, 15 hours of laboratory sessions or workshops with the remaining 100 hours reading and thinking about the content as well as working on assignments and  mid-semester test preparation.

Other Information

There are a total of six items of coursework worth a total of 45% of the marks. Five face-to-face assignment sessions scheduled and one self-directed online learning assignment. These comprise four laboratory-based assignments (8% each) focussed on disease processes in selected organ systems (liver, kidney and skin) a workshop session based on immunopathology with the lung as an example organ (5%), an oral poster presentation (8%) and a self-directed online learning assignment on genetic disease (8%).  

Digital Resources

Course materials are made available in a learning and collaboration tool called Canvas which also includes reading lists and lecture recordings (where available).

Please remember that the recording of any class on a personal device requires the permission of the instructor.

Academic Integrity

The University of Auckland will not tolerate cheating, or assisting others to cheat, and views cheating in coursework as a serious academic offence. The work that a student submits for grading must be the student's own work, reflecting their learning. Where work from other sources is used, it must be properly acknowledged and referenced. This requirement also applies to sources on the internet. A student's assessed work may be reviewed against online source material using computerised detection mechanisms.

Inclusive Learning

All students are asked to discuss any impairment related requirements privately, face to face and/or in written form with the course coordinator, lecturer or tutor.

Student Disability Services also provides support for students with a wide range of impairments, both visible and invisible, to succeed and excel at the University. For more information and contact details, please visit the Student Disability Services’ website at http://disability.auckland.ac.nz

Special Circumstances

If your ability to complete assessed coursework is affected by illness or other personal circumstances outside of your control, contact a member of teaching staff as soon as possible before the assessment is due.

If your personal circumstances significantly affect your performance, or preparation, for an exam or eligible written test, refer to the University’s aegrotat or compassionate consideration page: https://www.auckland.ac.nz/en/students/academic-information/exams-and-final-results/during-exams/aegrotat-and-compassionate-consideration.html.

This should be done as soon as possible and no later than seven days after the affected test or exam date.

Student Feedback

At the end of every semester students will be invited to give feedback on the course and teaching through a tool called SET or Qualtrics. The lecturers and course co-ordinators will consider all feedback and respond with summaries and actions.

Your feedback helps teachers to improve the course and its delivery for future students.

Class Representatives in each class can take feedback to the department and faculty staff-student consultative committees.

Overall those who responded to SET evaluations for this course were satisfied with the quality of MEDSCI 301. In particular the organisation of the course was good & the content intellectually stimulating. The aims of the course were clear and the assessments supported the course aims. Open-ended comments highlighted several things helpful for learning: such as the interesting labs (especially the poster session) and the variety of lecturers teaching on the course.

We do try to consider student concerns about the amount of content taught in this course and have addressed this in previous years. In 2020 we have introduced end-of-module tutorials/workshops that will be scheduled into timetabled lecture slots. These will provide students with a re-cap of content taught in the previous module before moving onto the next module/theme. This should help embed the material delivered in a more holistic manner and decrease the overall number of lectures delivered, thereby decreasing the amount of content.

Student Charter and Responsibilities

The Student Charter assumes and acknowledges that students are active participants in the learning process and that they have responsibilities to the institution and the international community of scholars. The University expects that students will act at all times in a way that demonstrates respect for the rights of other students and staff so that the learning environment is both safe and productive. For further information visit Student Charter (https://www.auckland.ac.nz/en/students/forms-policies-and-guidelines/student-policies-and-guidelines/student-charter.html).

Disclaimer

Elements of this outline may be subject to change. The latest information about the course will be available for enrolled students in Canvas.

In this course you may be asked to submit your coursework assessments digitally. The University reserves the right to conduct scheduled tests and examinations for this course online or through the use of computers or other electronic devices. Where tests or examinations are conducted online remote invigilation arrangements may be used. The final decision on the completion mode for a test or examination, and remote invigilation arrangements where applicable, will be advised to students at least 10 days prior to the scheduled date of the assessment, or in the case of an examination when the examination timetable is published.

Published on 31/07/2020 08:37 a.m.