MEDSCI 715 : Molecular Toxicology
Medical and Health Sciences
2020 Semester One (1203) (15 POINTS)
Course Prescription
Course Overview
This course involves advanced study into the role of metabolism (including induction/inhibition and genetic polymorphisms) in the toxicity of xenobiotics and molecular events following exposure to toxic xenobiotics, such as mutagenesis, teratogenesis and apoptosis. The toxicity of several classes of drugs, including anticancer, antibacterial and antimalarial drugs is also studied in detail
Capabilities Developed in this Course
| Capability 1: | Disciplinary Knowledge and Practice |
| Capability 2: | Critical Thinking |
| Capability 3: | Solution Seeking |
| Capability 4: | Communication and Engagement |
| Capability 5: | Independence and Integrity |
| Capability 6: | Social and Environmental Responsibilities |
Learning Outcomes
- Demonstrate an understanding of the principles important to predicting adverse reactions to compounds, whether they be under development as a drug or through environmental exposure (Capability 1 and 2)
- Demonstrate a comprehensive knowledge of biological targets and the damage caused to such targets plus some of the ensuing changes at the level of organelle, cell, organ and organism (Capability 1, 2 and 4)
- Evaluate the relevance of non-clinical species to the prediction of human drug safety (Capability 1, 4 and 6)
- Apply scientific reasoning and methods to experimental design for assessment of chemical toxicity (Capability 1, 2, 3 and 4)
- Apply critical evaluation to identify the essentials of scientific information in written reports and oral presentation (Capability 1, 2, 4 and 5)
Assessments
| Assessment Type | Percentage | Classification |
|---|---|---|
| Assignments | 40% | Individual Coursework |
| Final Exam | 60% | Individual Examination |
| 2 types | 100% |
| Assessment Type | Learning Outcome Addressed | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||||||
| Assignments | ||||||||||
| Final Exam | ||||||||||
Workload Expectations
This course is a standard 15 point course and students are expected to spend 10 hours per week involved in each 15 point course that they are enrolled in.
For this course, you can expect 2 hours of lectures and 2 hours of reading and thinking about the content per week and 102 hours of work on assignments and exam preparation.
Digital Resources
Course materials are made available in a learning and collaboration tool called Canvas which also includes reading lists and lecture recordings (where available).
Please remember that the recording of any class on a personal device requires the permission of the instructor.
Academic Integrity
The University of Auckland will not tolerate cheating, or assisting others to cheat, and views cheating in coursework as a serious academic offence. The work that a student submits for grading must be the student's own work, reflecting their learning. Where work from other sources is used, it must be properly acknowledged and referenced. This requirement also applies to sources on the internet. A student's assessed work may be reviewed against online source material using computerised detection mechanisms.
Inclusive Learning
All students are asked to discuss any impairment related requirements privately, face to face and/or in written form with the course coordinator, lecturer or tutor.
Student Disability Services also provides support for students with a wide range of impairments, both visible and invisible, to succeed and excel at the University. For more information and contact details, please visit the Student Disability Services’ website at http://disability.auckland.ac.nz
Special Circumstances
If your ability to complete assessed coursework is affected by illness or other personal circumstances outside of your control, contact a member of teaching staff as soon as possible before the assessment is due.
If your personal circumstances significantly affect your performance, or preparation, for an exam or eligible written test, refer to the University’s aegrotat or compassionate consideration page: https://www.auckland.ac.nz/en/students/academic-information/exams-and-final-results/during-exams/aegrotat-and-compassionate-consideration.html.
This should be done as soon as possible and no later than seven days after the affected test or exam date.
Student Feedback
At the end of every semester students will be invited to give feedback on the course and teaching through a tool called SET or Qualtrics. The lecturers and course co-ordinators will consider all feedback and respond with summaries and actions.
Your feedback helps teachers to improve the course and its delivery for future students.
Class Representatives in each class can take feedback to the department and faculty staff-student consultative committees.
Student Charter and Responsibilities
The Student Charter assumes and acknowledges that students are active participants in the learning process and that they have responsibilities to the institution and the international community of scholars. The University expects that students will act at all times in a way that demonstrates respect for the rights of other students and staff so that the learning environment is both safe and productive. For further information visit Student Charter (https://www.auckland.ac.nz/en/students/forms-policies-and-guidelines/student-policies-and-guidelines/student-charter.html).
Disclaimer
Elements of this outline may be subject to change. The latest information about the course will be available for enrolled students in Canvas.
In this course you may be asked to submit your coursework assessments digitally. The University reserves the right to conduct scheduled tests and examinations for this course online or through the use of computers or other electronic devices. Where tests or examinations are conducted online remote invigilation arrangements may be used. The final decision on the completion mode for a test or examination, and remote invigilation arrangements where applicable, will be advised to students at least 10 days prior to the scheduled date of the assessment, or in the case of an examination when the examination timetable is published.