MEDSCI 721 : Advanced Toxicology

Medical and Health Sciences

2021 Semester Two (15 POINTS)

Course Prescription

Focuses on classes of drugs associated with idiosyncratic adverse reactions and studies to define their metabolic basis and assessment of toxic risk.

Course Overview

This course considers the value of models of toxicity for the mechanistic understanding and predictability of factors that can result in toxic reaction in humans. The course is aimed primarily at students wishing to undertake research in a field related to toxicology.

Course Requirements

No pre-requisites or restrictions

Course Contacts

Malcolm Tingle (

Capabilities Developed in this Course

Capability 1: Disciplinary Knowledge and Practice
Capability 2: Critical Thinking
Capability 4: Communication and Engagement
Capability 5: Independence and Integrity
Capability 6: Social and Environmental Responsibilities

Learning Outcomes

By the end of this course, students will be able to:
  1. Articulate and demonstrate a comprehensive knowledge of why toxicology testing is required (Capability 1, 2 and 5)
  2. Demonstrate an understanding of how toxicity can be influenced by factors such as the dose and route of exposure; the effect of acute versus chronic exposure; the end-points selected and the importance of delayed effects. (Capability 1, 2, 5 and 6)
  3. Demonstrate an understanding of the relevance of non-clinical species to the prediction of human drug safety (Capability 1, 2 and 6)
  4. Communicate the essentials of scientific information in written reports and oral presentations (Capability 1, 4 and 5)


Assessment Type Percentage Classification
Assignment 1 50% Individual Coursework
Assignment 2 50% Individual Coursework
Assessment Type Learning Outcome Addressed
1 2 3 4
Assignment 1
Assignment 2

Workload Expectations

This course is a standard 15 point course and students are expected to spend 10 hours per week involved in each 15 point course that they are enrolled in.

For this course, you can expect 48 hours of tutorials and 102 hours of self-directed learning.

Delivery Mode

Campus Experience

Attendance is required at scheduled activities including tutorials to receive credit for components of the course.
Lectures will be available as recordings. Other learning activities including tutorials will not be available as recordings.
The course will include live online events including group discussions/tutorials.
The activities for the course are scheduled as a standard weekly timetable.

Learning Resources

This course is based on the interpretation of primary literature available through the University library

Student Feedback

At the end of every semester students will be invited to give feedback on the course and teaching through a tool called SET or Qualtrics. The lecturers and course co-ordinators will consider all feedback and respond with summaries and actions.

Your feedback helps teachers to improve the course and its delivery for future students.

Class Representatives in each class can take feedback to the department and faculty staff-student consultative committees.

Digital Resources

Course materials are made available in a learning and collaboration tool called Canvas which also includes reading lists and lecture recordings (where available).

Please remember that the recording of any class on a personal device requires the permission of the instructor.

Academic Integrity

The University of Auckland will not tolerate cheating, or assisting others to cheat, and views cheating in coursework as a serious academic offence. The work that a student submits for grading must be the student's own work, reflecting their learning. Where work from other sources is used, it must be properly acknowledged and referenced. This requirement also applies to sources on the internet. A student's assessed work may be reviewed against online source material using computerised detection mechanisms.

Inclusive Learning

All students are asked to discuss any impairment related requirements privately, face to face and/or in written form with the course coordinator, lecturer or tutor.

Student Disability Services also provides support for students with a wide range of impairments, both visible and invisible, to succeed and excel at the University. For more information and contact details, please visit the Student Disability Services’ website

Special Circumstances

If your ability to complete assessed coursework is affected by illness or other personal circumstances outside of your control, contact a member of teaching staff as soon as possible before the assessment is due.

If your personal circumstances significantly affect your performance, or preparation, for an exam or eligible written test, refer to the University’s aegrotat or compassionate consideration page

This should be done as soon as possible and no later than seven days after the affected test or exam date.

Learning Continuity

In the event of an unexpected disruption we undertake to maintain the continuity and standard of teaching and learning in all your courses throughout the year. If there are unexpected disruptions the University has contingency plans to ensure that access to your course continues and your assessment is fair, and not compromised. Some adjustments may need to be made in emergencies. You will be kept fully informed by your course co-ordinator, and if disruption occurs you should refer to the University Website for information about how to proceed.

The delivery mode of this course may change in accordance with changes to New Zealand Government recommendations. Updates for this course will be provided on the course Canvas page.
This course may be taken remotely  if you meet Ministry of Health guidelines and receive an exemption, or are unable to attend because of border restrictions.
Level 1: All main teaching activities will be conducted on campus and in person.
• Tutorials: on campus, remote versions will be available.  

Level 2: All teaching activities are remote
• Tutorials: delivered remotely, available at the timetabled time and recorded versions will be available

Level 3/4: All teaching activities are remote 
• Tutorials: delivered remotely, available at the timetabled time and recordings of the sessions/online versions will be available.

Student Charter and Responsibilities

The Student Charter assumes and acknowledges that students are active participants in the learning process and that they have responsibilities to the institution and the international community of scholars. The University expects that students will act at all times in a way that demonstrates respect for the rights of other students and staff so that the learning environment is both safe and productive. For further information visit Student Charter


Elements of this outline may be subject to change. The latest information about the course will be available for enrolled students in Canvas.

In this course you may be asked to submit your coursework assessments digitally. The University reserves the right to conduct scheduled tests and examinations for this course online or through the use of computers or other electronic devices. Where tests or examinations are conducted online remote invigilation arrangements may be used. The final decision on the completion mode for a test or examination, and remote invigilation arrangements where applicable, will be advised to students at least 10 days prior to the scheduled date of the assessment, or in the case of an examination when the examination timetable is published.